There are certainly a couple of things you can do to improve both the flight and your holiday.
Some things you can prepare before even you take off. If you are going on a long, transatlantic flight, choose a connection at a time when your child is most likely to sleep a large part of the way.
You can start adapting to the new time zone a few days before you leave by getting up and going to bed earlier than usual.
Prepare a couple of small bags with toys to play with during the flight, especially if travelling with small children. That way you can always pull out a new bag to keep your child entertained. We have also found that it works well to pack small snacks like raisins, muesli bars and wafers. But keep an eye on the sugar content. Sugar gives children extra energy that they won’t be able to use up.